Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjögren's syndrome: Novel biomarkers for disease activity and subsets.
Jacob RitterFranziska SzelinskiArman AueAna-Luisa StefanskiHector Rincon-ArevaloYidan ChenEduard NitschkeVan Duc DangAnnika WiedemannEva SchrezenmeierAndreia C LinoThomas DörnerPublished in: Journal of autoimmunity (2024)
Here, we provide evidence that in active pSS patients, enhanced IFN signaling incl. unphosphorylated STAT1 and STAT2 with IRFs entertain chronic T and B cell activation. Furthermore, increased STAT1 levels candidate as biomarker of extraglandular disease, while IRF9 levels can serve as biomarker for disease activity.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- rheumatoid arthritis patients
- ankylosing spondylitis
- cell proliferation
- juvenile idiopathic arthritis
- end stage renal disease
- dendritic cells
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- case report