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Mesenchymal stem cells and porous β-tricalcium phosphate composites prepared through stem cell screen-enrich-combine(-biomaterials) circulating system for the repair of critical size bone defects in goat tibia.

Wenxiang ChuYaokai GanYifu ZhuangXin WangJie ZhaoTingting TangKerong Dai
Published in: Stem cell research & therapy (2018)
The MSCs/β-TCP prepared through SECCS demonstrated significant therapeutic efficacy in goat models of critical size bone defect. This provides a novel therapeutic strategy for critical size bone defects caused by severe injury, infection, and bone tumor resection with a high profile of safety, effectiveness, simplicity, and ease.
Keyphrases
  • bone regeneration
  • mesenchymal stem cells
  • bone mineral density
  • stem cells
  • soft tissue
  • bone loss
  • randomized controlled trial
  • systematic review
  • umbilical cord
  • high throughput
  • bone marrow