Complete reversal of bilateral optic nerve infiltration from lymphoblastic leukemia using chemotherapy without adjuvant radiotherapy.
Douglas Rodrigues da CostaRodrigo Dahia FernandesFernanda Nicolela SusannaEpitácio Dias da Silva NetoMário Luiz Ribeiro MonteiroPublished in: BMC ophthalmology (2021)
Leukemia relapse on central nervous system, despite rare, is a sign of poor prognosis and requires prompt treatment. Its occurrence on ocular tissues is even rarer. It is hypothesized that the blood-brain barrier limits the delivery of chemotherapeutic drugs to the eye and infiltration of the optic nerve by leukemic cells might prejudice the flow of cerebrospinal fluid between the cranial space and the optic disc.
Keyphrases
- optic nerve
- poor prognosis
- cerebrospinal fluid
- acute myeloid leukemia
- long non coding rna
- optical coherence tomography
- early stage
- locally advanced
- induced apoptosis
- bone marrow
- cell cycle arrest
- gene expression
- risk assessment
- radiation induced
- cell death
- squamous cell carcinoma
- signaling pathway
- oxidative stress
- cell proliferation
- pi k akt