Long non-coding RNA HOTAIR induces the PI3K/AKT/mTOR signaling pathway in breast cancer cells.

Mona Sadeghalvad Kamran Mansouri Hamid-Reza Mohammadi-Motlagh Farshid Noorbakhsh Ali Mostafaie Sadaf Alipour Nima Rezaei

Published in: Revista da Associacao Medica Brasileira (1992) (2022)

This study may introduce HOX antisense intergenic RNA as a molecule involved in the upregulation of the phosphoinositide 3-kinase/protein kinase AKT/mammalian target of rapamycin signaling pathway in breast cancer cells that may contribute to breast cancer cell proliferation.

Keyphrases

signaling pathway
long non coding rna
breast cancer cells
cell proliferation
pi k akt
poor prognosis
protein kinase
epithelial mesenchymal transition
induced apoptosis
cell cycle
nucleic acid
tyrosine kinase