Transcriptome analysis of the fish pathogen Flavobacterium columnare in biofilm suggests calcium role in pathogenesis.
Wenlong CaiLeonardo De La FuenteCovadonga R AriasPublished in: BMC microbiology (2019)
Our results posit Ca2+ as a critical signal in regulating bacterial surface adhesion and biofilm formation in F. columnare. Living in biofilm elicited a shift in several metabolic pathways that allowed the cells to cope with oxidative stress and nutrient starvation. In addition, Ca2+ supplementation induced the expression of putative virulence factors in F. columnare, such as extracellular protein secretion and iron acquisition.
Keyphrases
- biofilm formation
- candida albicans
- pseudomonas aeruginosa
- induced apoptosis
- oxidative stress
- staphylococcus aureus
- diabetic rats
- escherichia coli
- poor prognosis
- cell cycle arrest
- cystic fibrosis
- binding protein
- endoplasmic reticulum stress
- protein kinase
- dna damage
- signaling pathway
- ischemia reperfusion injury
- drug induced
- cell death
- protein protein