(Very) Small Stem-like Cells in Human Cell Cultures.
Jan Jakub LicaBhaskar PradhanPublished in: Cancers (2023)
Very Small Embryonic-like Stem Cells (VSELSCs) and Very Small Cancer Stem Cells (VSCSCs) are fields of intensive research. Although the presence in vitro of VSELSC and VSCSC cellular stage analogs appear probable, it has yet to be published. Utilizing established human cell cultures with varying populations of primitive cells, stained with CD markers specific to primitive stages, in addition to a fluorescent DNA dye, and following histochemical processing, we have developed a cytological method for detecting Very Small Leukemic Stem-like Cells (VSLSLCs), Very Small Cancer Stem-like Cells (VSCSLCs), and VSELSCs. This detection provides an opportunity to advance research in these areas.
Keyphrases
- stem cells
- endothelial cells
- cell therapy
- single cell
- cancer stem cells
- induced pluripotent stem cells
- acute myeloid leukemia
- squamous cell carcinoma
- randomized controlled trial
- signaling pathway
- systematic review
- cell proliferation
- oxidative stress
- young adults
- cell cycle arrest
- label free
- bone marrow
- quantum dots
- single molecule
- living cells
- pi k akt
- fluorescent probe