Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance.
Hao MeiJeannette SiminoLianna LiFan JiangJoshua C BisGail DaviesW David HillCharley XiaVilmundur GudnasonQiong YangJari LahtiJennifer A SmithMirna KirinPhilip De JagerNicola J ArmstrongMohsen GhanbariIvana KolcicChristopher MoranAlexander TeumerMurali SargurupremrajShamsed MahmudMyriam FornageWei ZhaoClaudia L SatizabalOzren PolasekKatri RäikkönenDavid C LiewaldGeorg HomuthMichele CallisayaKaren A MatherB Gwen WindhamTatijana ZemunikAarno PalotieAlison PattieSandra van der AuweraAnbupalam ThalamuthuDavid S KnopmanIgor RudanJohn M StarrKatharina WittfeldNicole A KochanMichael E GriswoldVeronique VitartHenry BrodatyRebecca GottesmanSimon R CoxBruce M PsatyEric BoerwinkleDaniel I ChasmanFrancine GrodsteinPerminder S SachdevVelandai SrikanthCaroline HaywardJames F WilsonJohan G ErikssonSharon L R KardiaHans J GrabeDavid A BennettM Arfan IkramIan J DearyCornelia M van DuijnLenore LaunerAnnette L FitzpatrickSudha SeshadriJan BresslerStephanie DebetteThomas H MosleyPublished in: Alzheimer's research & therapy (2024)
VDM genetic associations influence expression regulation via eQTLs and meQTLs. The involvement of TFs, microRNAs, MHC genes, and immune-related pathways contributes to VDM performance in older individuals.