Dopaminergic neuromodulation has no detectable effect on visual-cue induced haemodynamic response function in the visual cortex: A double-blind, placebo-controlled functional magnetic resonance imaging study.
Andrei ManoliuRonald SladkySigrid ScherpietLutz JänckeMatthias KirschnerAmelie HauggJulia BolsingerRainer KraehenmannPhilipp StämpfliFrank ScharnowskiUwe HerwigErich SeifritzAnnette B BrühlPublished in: Journal of psychopharmacology (Oxford, England) (2020)
The aim of this study was to investigate the effect of acute dopamine agonistic and antagonistic manipulation on the visual-cue induced blood oxygen level-dependent signal response in healthy volunteers. Seventeen healthy volunteers in a double-blind placebo-controlled cross-over design received either a dopamine antagonist, agonist or placebo and underwent functional magnetic resonance imaging. Using classical inference and Bayesian statistics, we found no effect of dopaminergic modulation on properties of visual-cue induced blood oxygen level-dependent signals in the visual cortex, particularly on distinct properties of the haemodynamic response function (amplitude, time-to-peak and width). Dopamine-related effects modulating the neurovascular coupling in the visual cortex might be negligible when measured via functional magnetic resonance imaging.
Keyphrases
- magnetic resonance imaging
- placebo controlled
- high glucose
- diabetic rats
- drug induced
- double blind
- computed tomography
- liver failure
- endothelial cells
- metabolic syndrome
- magnetic resonance
- phase iii
- oxidative stress
- squamous cell carcinoma
- randomized controlled trial
- rectal cancer
- study protocol
- intensive care unit
- phase ii study
- hepatitis b virus
- room temperature