Oocyte Maturation and miRNAs: Studying a Complicate Interaction to Reveal Possible Biomarkers for Female Infertility.
Eleni NazouAnastasios PotirisDespoina MavrogianniEirini DrakakiAris-Anargyros VogiatzisVaia SarliTereza VrantzaAthanasios ZikopoulosKonstantinos LouisChara SkentouPeriklis PanagopoulosPeter DrakakisSofoklis StavrosPublished in: Diseases (Basel, Switzerland) (2024)
Cellular metabolism, apoptosis, fertilization, and proliferation of granulosa cells belong to a battery of processes where microRNAs can be detected and associated with infertility. The aim of the present review is to focus on mammalian oocyte maturation events and the association between oocyte growth and miRNA expression. PubMed/Medline, Google Scholar and Scopus databases were searched, and 33 studies were included. Regarding the correlation among miRNA expression and the regulation of granulosa cells and cumulus cells, the most important miRNAs were let-7b, let-7c and miR-21. Additionally, the loss of Dicer, an enzyme involved in miRNA biogenesis, is probably a crucial factor in oogenesis, oocyte maturation and embryogenesis. Furthermore, miRNAs interfere with different cellular mechanisms like apoptosis, steroidogenesis, genome integrity, angiogenesis, antioxidative response and, consequently, oocyte maturation. Hence, it is of major importance to clarify the role and mechanism of each miRNA as understanding its action may develop new tools and establish new diagnostic and treatment approaches for infertility and ovarian disorders.
Keyphrases
- cell cycle arrest
- induced apoptosis
- cell death
- endoplasmic reticulum stress
- polycystic ovary syndrome
- poor prognosis
- pi k akt
- oxidative stress
- signaling pathway
- cell proliferation
- long non coding rna
- type diabetes
- gene expression
- metabolic syndrome
- adipose tissue
- endothelial cells
- combination therapy
- long noncoding rna
- artificial intelligence
- solid state