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Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting.

Sebastian GreppmairAlexander BrinkmannAnka RoehrOtto FreyStefan HagelChristoph DornAmélie MarsotIbrahim El-HaffafMichael ZollerThomas SallerJohannes ZanderLea Marie SchatzChristina ScharfJosef BriegelIris K MinichmayrSebastian G WichaUwe Liebchen
Published in: Intensive care medicine (2023)
The predictive performance of published PIP models in ICU patients varied considerably, highlighting the relevance of appropriate model selection for MIPD. Our differentiated external evaluation identified specific models suitable for clinical use, especially in combination with TDM.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • intensive care unit
  • peritoneal dialysis
  • prognostic factors
  • clinical trial
  • cross sectional