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Landscape of Genetic Alterations Underlying Hallmark Signature Changes in Cancer Reveals TP53 Aneuploidy-driven Metabolic Reprogramming.

Marni B SiegelYasunori KogureNaser Ansari-PourYuki SaitoHann-Hsiang ChaoJonathan H ShepherdMariko TabataOlufunmilayo I OlopadeDavid C WedgeKatherine A HoadleyCharles M PerouKeisuke Kataoka
Published in: Cancer research communications (2023)
mutation and a resultant selected pattern of aneuploidies cause an aggressive transcriptional program including upregulation of glycolysis signature with prognostic implications. Importantly, basal-like breast cancer demonstrates genetic and/or phenotypic changes closely related to squamous tumors including 5q deletion that reveal alterations that could offer therapeutic options across tumor types regardless of tissue of origin.
Keyphrases
  • genome wide
  • papillary thyroid
  • single cell
  • copy number
  • gene expression
  • dna methylation
  • quality improvement
  • poor prognosis
  • high grade
  • squamous cell
  • oxidative stress
  • heat shock
  • young adults
  • heat stress