S6 Kinase Reflects and Regulates Ethanol-Induced Sedation.
Summer F AcevedoRaniero L Peru y Colón de PortugalDante A GonzalezAylin R RodanAdrian RothenfluhPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)
Genetic factors play a major role in the development of addiction. Identifying these genes and understanding their molecular mechanisms is a necessary first step in the development of targeted therapeutic intervention. Here, we show that signaling from the insulin receptor in Drosophila neurons determines flies' sensitivity to ethanol-induced sedation. We show that this signaling cascade includes the small GTPase Arf6 and S6 kinase (S6k). In addition, activity of S6k is regulated by acute ethanol exposure and by neuronal activity. S6k activity is therefore both an acute target of ethanol exposure and a regulator of ethanol's effects on behavior.
Keyphrases
- drug induced
- high glucose
- diabetic rats
- genome wide
- type diabetes
- respiratory failure
- randomized controlled trial
- mechanical ventilation
- spinal cord
- gene expression
- aortic dissection
- transcription factor
- tyrosine kinase
- oxidative stress
- endothelial cells
- adipose tissue
- intensive care unit
- drug delivery
- dna methylation
- binding protein
- weight loss
- cerebral ischemia