Diagnostic accuracy of a sequence-specific Mtb -DNA hybridization assay in urine: a case-control study including subclinical TB cases.
Yves TschanMohamed SasamaloHellen HizaJacques FellaySébastien GagneuxKlaus ReitherJerry HellaDamien PortevinPublished in: Microbiology spectrum (2024)
that is shed in the urine of tuberculosis patients. We present accuracy data that would fulfill the target product profile for a non-sputum test. In addition, recent epidemiological data suggested that up to 50% of individuals secreting live bacilli do not present with symptoms at the time of screening. We report, here, that the investigated index test could also detect instances of asymptomatic TB infections among household contacts.
Keyphrases
- mycobacterium tuberculosis
- pulmonary tuberculosis
- end stage renal disease
- electronic health record
- chronic kidney disease
- ejection fraction
- newly diagnosed
- big data
- peritoneal dialysis
- single molecule
- cystic fibrosis
- prognostic factors
- machine learning
- circulating tumor
- mass spectrometry
- cell free
- emergency department
- gram negative
- depressive symptoms
- high resolution
- atomic force microscopy
- deep learning
- single cell
- sleep quality
- amino acid
- adverse drug