Knocking-down long non-coding RNA LINC01094 prohibits chondrocyte apoptosis via regulating microRNA-577/metal-regulatory transcription factor 1 axis.

Feiri HuangZhongliang SuJie YangXizhen ZhaoYaozeng Xu

Published in: Journal of orthopaedic surgery (Hong Kong) (2024)

Silencing of LINC01094 represses the apoptosis of chondrocytes through upregulating miR-577 expression and downregulating MTF1 levels, providing a preliminary insight for the treatment of OA in the future.

Keyphrases

long non coding rna
poor prognosis
transcription factor
endoplasmic reticulum stress
oxidative stress
cell cycle arrest
cell death
cell proliferation
dna binding
current status
knee osteoarthritis
binding protein
pi k akt
signaling pathway
combination therapy
smoking cessation