FADD amplification is associated with CD8 + T-cell exclusion and malignant progression in HNSCC.

Yang Zheng Surui ShengYanni MaYinan ChenRuixin LiuWuchang ZhangLi ZhangZhonglong LiuYue HeHanlin ZengZhiyuan Zhang

Published in: Oral diseases (2024)

Our preliminary investigation has discovered the association between FADD expression and the immunosuppressive microenvironment in HNSCC. Due to the high frequent amplification of the chromosomal region 11q13.3, where FADD is located, targeting FADD holds promise for improving the immune-inactive state of tumors, subsequently inhibiting HNSCC tumor progression.

Keyphrases

poor prognosis
nucleic acid
stem cells
signaling pathway
big data
gene expression
cancer therapy
copy number
label free
binding protein
dna methylation
deep learning