Targeting Fc Receptor-Mediated Effects and the "Don't Eat Me" Signal with an Oncolytic Virus Expressing an Anti-CD47 Antibody to Treat Metastatic Ovarian Cancer.

Lei TianBo XuKun-Yu TengMihae SongZheng ZhuYuqing ChenJing WangJianying ZhangMingye FengBalveen KaurLorna RodriguezMichael A CaligiuriJianhua Yu

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Our data demonstrate that an oHSV encoding a full-length human IgG1 anti-CD47 mAb, when used as a single agent or combined with another agent, is a promising approach for improving ovarian cancer treatment via enhancing innate immunity, as well as performing its known oncolytic function and modulation of immune cells.

Keyphrases

endothelial cells
squamous cell carcinoma
small cell lung cancer
nk cells
electronic health record
cancer therapy
big data
pluripotent stem cells