Strategy to prevent epitope masking in CAR.CD19+ B-cell leukemia blasts.

Concetta QuintarelliMarika GuercioSimona ManniIolanda BoffaMatilde SinibaldiStefano Di CeccaSimona CarusoZeinab AbbaszadehAntonio CameraBiancamaria CembrolaRoselia CicconeAlberto OrfaoLourdes Martin-MartinSara Gutierrez-HerreroMaria Herrero-GarciaGiovanni CazzanigaVittorio NunesSimona SongiaPaolo MarcatiliFrederikke I MarinMarco RuellaValentina BertainaLuciana VintiFrancesca Del BufaloMattia AlgeriPietro MerliBiagio De AngelisFranco Locatelli

Published in: Journal for immunotherapy of cancer (2022)

Taken together, these data suggest that a VL-VH SL may result in a safe CAR-T product, even when manufacturing starts from biological materials characterized by heavy contamination of leukemia blasts.

Keyphrases

acute myeloid leukemia
bone marrow
risk assessment
electronic health record
drinking water
big data
human health
machine learning
artificial intelligence
data analysis
climate change