Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity.
Wei FengYuan ZhouLing-Yu ZhouLi-Ying KangXiang WangBao-Lin LiQing LiLi-Ying NiuPublished in: Molecules (Basel, Switzerland) (2019)
Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A⁻E (1⁻5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1⁻5 were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC50 ranging from 5.9 to 33.9 μM compared to Cisplatin.
Keyphrases
- solid phase extraction
- endothelial cells
- liquid chromatography
- ms ms
- cell cycle arrest
- simultaneous determination
- molecular docking
- high performance liquid chromatography
- mass spectrometry
- electronic health record
- induced pluripotent stem cells
- big data
- tandem mass spectrometry
- pluripotent stem cells
- wound healing
- signaling pathway
- artificial intelligence
- cell proliferation