Enhanced expression of angiotensin-converting enzyme 2 in psoriatic skin and its upregulation in keratinocytes by interferon-γ: implication of inflammatory milieu in skin tropism of SARS-CoV-2.
Manoj Kumar TembhreA S PariharV K SharmaS ImranN BhariR LakshmyA BhallaPublished in: The British journal of dermatology (2020)
The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a challenging situation globally due to its contagion nature. SARS-CoV-2 enters the host cell by interacting with the ACE2 (angiotensin converting enzyme 2) receptor present on cell surface through its receptor-binding domain (RBD) of spike protein (1). Host proteases mainly TMPRSS2 plays a vital role in cleaving the SARS-CoV-2 spike protein thereby enabling the virus to enter host cell via endocytosis. SARS-CoV-2 mainly affects the respiratory system of the infected host, however, its manifestation to other organs have also been reported (2).
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- angiotensin converting enzyme
- angiotensin ii
- coronavirus disease
- binding protein
- poor prognosis
- cell surface
- single cell
- cell therapy
- rheumatoid arthritis
- wound healing
- stem cells
- ankylosing spondylitis
- dendritic cells
- small molecule
- soft tissue
- systemic lupus erythematosus
- long non coding rna
- disease activity
- mesenchymal stem cells
- respiratory tract