Ethanol-mediated suppression of IL-37 licenses alcoholic liver disease.

Felix GrabherrChristoph GranderTimon E AdolphVerena WieserLisa MayrBarbara EnrichSophie MacheinerMoris SanginetoAndreas ReiterAndre ViveirosHeinz ZollerPhilip BuflerAlexander R MoschenCharles A DinarelloHerbert Tilg

Published in: Liver international : official journal of the International Association for the Study of the Liver (2017)

We provide evidence for an exogenous noxae that suppresses Interleukin 37 expression which limits its anti-inflammatory effects in alcoholic liver disease.

Keyphrases

liver injury
poor prognosis

drug induced
signaling pathway

binding protein

long non coding rna