Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.

Michal NemergutSérgio M MarquesLukas UhrikTereza VanovaMarketa NezvedovaDarshak Chandulal GadaraDurga JhaJan TulisVeronika NovakovaJoan Planas-IglesiasAntonin KunkaAnthony LegrandHana HribkovaVeronika PospisilovaJiri SedmikJan RaskaZbynek ProkopJiri DamborskyDasa BohaciakovaZdenek SpacilLenka HernychovaDavid BednarMartin Marek

Published in: Molecular neurodegeneration (2023)

Our results connect the ApoE4 structure with its aggregation propensity, providing a new druggable target for neurodegeneration and ageing.

Keyphrases

cognitive decline
mild cognitive impairment
high fat diet
metabolic syndrome
emergency department
type diabetes
drug induced
insulin resistance
adipose tissue