Single-nucleotide polymorphisms and the effectiveness of taxane-based chemotherapy in premenopausal breast cancer: a population-based cohort study in Denmark.

Cathrine Fonnesbech HjorthPer DamkierTore B StageSøren FeddersenStephen Hamilton-DutoitMikael RørthBent EjlertsenTimothy L LashThomas P AhernHenrik T SørensenDeirdre Cronin-Fenton

Published in: Breast cancer research and treatment (2022)

Docetaxel effectiveness was influenced by SNPs in GSTP1, CYP3A, and SLCO1B1 in premenopausal women with non-distant metastatic breast cancer, likely related to altered docetaxel pharmacokinetics. These SNPs may help determine individual benefit from taxane-based chemotherapy.

Keyphrases

metastatic breast cancer
locally advanced
randomized controlled trial
postmenopausal women
rectal cancer
systematic review
genome wide
squamous cell carcinoma
breast cancer risk
radiation therapy
lymph node
genome wide association
early breast cancer
dna methylation
young adults
gene expression
drug induced