Mitophagy, a crucial pathway in eukaryotic cells, selectively eliminates dysfunctional mitochondria, thereby maintaining cellular homeostasis via mitochondrial quality control. Pulmonary hypertension (PH) refers to a pathological condition where pulmonary arterial pressure is abnormally elevated due to various reasons, and the underlying pathogenesis remains elusive. This article examines the molecular mechanisms underlying mitophagy, emphasizing its role in PH and the progress in elucidating related molecular signaling pathways. Additionally, it highlights current drug regulatory pathways, aiming to provide novel insights into the prevention and treatment of pulmonary hypertension.
Keyphrases
- pulmonary hypertension
- quality control
- pulmonary artery
- induced apoptosis
- pulmonary arterial hypertension
- nlrp inflammasome
- signaling pathway
- randomized controlled trial
- cell cycle arrest
- oxidative stress
- cell death
- transcription factor
- single molecule
- pi k akt
- cancer therapy
- emergency department
- reactive oxygen species
- drug delivery
- combination therapy
- adverse drug
- cell proliferation