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KSHV promotes oncogenic FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation.

Vladimir MajerciakBeatriz Alvarado-HernandezYanping MaShivalee DuduskarAlexei LobanovMargaret C CamZhi-Ming Zheng
Published in: bioRxiv : the preprint server for biology (2024)
promoter, thereby enhancing RGS2 expression and phosphorylation of AKT. Our data conclude that viral RNA-binding protein ORF57 controls the expression of a subset of genes for signaling, cell cycle progression, and proliferation to contribute viral pathogenesis.
Keyphrases
  • cell cycle
  • binding protein
  • cell proliferation
  • signaling pathway
  • poor prognosis
  • sars cov
  • transcription factor
  • dna methylation
  • gene expression
  • genome wide
  • electronic health record
  • big data
  • machine learning