KSHV promotes oncogenic FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation.

Vladimir MajerciakBeatriz Alvarado-HernandezYanping MaShivalee DuduskarAlexei LobanovMargaret C Cam Zhi-Ming Zheng

Published in: bioRxiv : the preprint server for biology (2024)

promoter, thereby enhancing RGS2 expression and phosphorylation of AKT. Our data conclude that viral RNA-binding protein ORF57 controls the expression of a subset of genes for signaling, cell cycle progression, and proliferation to contribute viral pathogenesis.

Keyphrases

cell cycle
binding protein
cell proliferation
signaling pathway
poor prognosis
sars cov
transcription factor
dna methylation
gene expression
genome wide
electronic health record
big data
machine learning