KSHV promotes oncogenic FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation.
Vladimir MajerciakBeatriz Alvarado-HernandezYanping MaShivalee DuduskarAlexei LobanovMargaret C CamZhi-Ming ZhengPublished in: bioRxiv : the preprint server for biology (2024)
promoter, thereby enhancing RGS2 expression and phosphorylation of AKT. Our data conclude that viral RNA-binding protein ORF57 controls the expression of a subset of genes for signaling, cell cycle progression, and proliferation to contribute viral pathogenesis.