Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non-Small Cell Lung Cancer.
David E GerberWilliam C PutnamFarjana J FattahKemp H KernstineRolf A BrekkenIvan PedrosaRachael SkeltonJessica M SaltarskiRobert E LenkinskiRichard D LeffChul AhnChyndhri PadmanabhanVaidehi ChembukarSahba KasiriRaja Reddy KallemIndhumathy SubramaniyanQing YuanQuyen N DoYin XiScott I ReznikLorraine PelosofBrandon FaubertRalph J DeBerardinisJames KimPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Itraconazole demonstrates concentration-dependent early antivascular, metabolic, and antitumor effects in patients with NSCLC. As the number of fixed dose cancer therapies increases, attention to interpatient pharmacokinetics and pharmacodynamics differences may be warranted.