Developmental programming in human umbilical cord vein endothelial cells following fetal growth restriction.
Fieke TerstappenJorg J A CalisNina D PaauwJaap A JolesBas B van RijnMichal MokryTorsten PlöschA Titia LelyPublished in: Clinical epigenetics (2020)
This study showed upregulation of gene sets related to renal development in HUVECs collected from pregnancies complicated by FGR compared to control donors. The differentially expressed gene sets related to cardiovascular function and health might be in line with the downregulated expression of NRM and upregulated expression of lincRNA RP5-855F14.1 in FGR samples; NRM is involved in cardiac remodeling, and lincRNAs are correlated with cardiovascular diseases. Future studies should elucidate whether the downregulated LGALS1 and FPR3 expressions in FGR are angiogenesis-modulating regulators leading to placental insufficiency-induced FGR or whether the expression of these genes can be used as a biomarker for increased cardiovascular risk. Altered DNA methylation might partly underlie FPR3 and NRM differential gene expression differences in a sex-dependent manner.
Keyphrases
- endothelial cells
- poor prognosis
- dna methylation
- gene expression
- genome wide
- high glucose
- umbilical cord
- mesenchymal stem cells
- cardiovascular disease
- copy number
- long non coding rna
- genome wide identification
- signaling pathway
- healthcare
- public health
- binding protein
- vascular endothelial growth factor
- transcription factor
- mental health
- pregnant women
- cell proliferation
- heart failure
- oxidative stress
- risk assessment
- cardiovascular risk factors
- cardiovascular events