JPHYD Inhibits miR-21-5p/Smad7-Mediated Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells.

Li-Hua Liu Chong-Kai FangFu-Cheng GeJi-Nan WangXiu-Bing ZhangRui Luo Ying Zhang Kun-Liang Feng Zhen-Wen Qiu Chong Zhong

Published in: Journal of oncology (2022)

Our results indicated that JPHYD inhibited epithelial-mesenchymal transition by increasing Smad7 expression and inhibiting miR-21-5p. Therefore, blocking the occurrence and development of EMT may be a new mechanism of JPHYD's anti-liver cancer effect.

Keyphrases

epithelial mesenchymal transition
signaling pathway
transforming growth factor
poor prognosis
risk assessment
binding protein