The inhibition of apoptosis through myocardial postconditioning by affecting Fas/FasIg signaling through miR139-3p and miR181a-1.
Gülnur AslanAhmet AtessahinEngin SahnaPublished in: Journal of cardiac surgery (2020)
The abovementioned genes can be used as important prognostic markers in the diagnosis of reperfusion injury and in the evaluation of treatment efficacy. It was further noted that increased expression of CYBB, which is one of the target genes for miR139-3p, and a decreased expression of miR181a-1 may cause apoptosis by affecting Fas and Faslg signaling. PostC can inhibit apoptosis by increasing miR139-3p and miR181a-1 levels.
Keyphrases
- long non coding rna
- poor prognosis
- cell proliferation
- endoplasmic reticulum stress
- oxidative stress
- cell cycle arrest
- long noncoding rna
- cell death
- genome wide
- cerebral ischemia
- ischemia reperfusion injury
- acute myocardial infarction
- left ventricular
- bioinformatics analysis
- genome wide identification
- dna methylation
- heart failure
- acute coronary syndrome
- atrial fibrillation