An explanatory sequential mixed-methods design to establish thresholds of within-individual meaningful change on a sleep disturbance numerical rating scale score in atopic dermatitis.
Carla Dias-BarbosaJorge PuellesFatoumata FofanaSylvie GabrielDanielle RodriguezRajeev ChavdaChristophe PikettyPublished in: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation (2022)
This research determined MWIC threshold estimates for the SD NRS score in both adolescents and adults with moderate-to-severe AD using an explanatory sequential mixed-methods design. This mixed-methods design provides interesting insights for establishing MWIC thresholds of a PRO score in the context of a drug development program.