Functional Analysis of RELN S2486G Mutation and its Contribution to Pathogenesis of Ankylosing Spondylitis.

Elika Esmaeilzadeh-Gharehdaghi Ehsan RazmaraAmirreza BitarafAhmadreza JamshidiMahdi MahmoudiMasoud Garshasbi

Published in: Archives of Iranian medicine (2020)

The S2486G mutation in RELN can alter inflammatory and, to some extent, osteogenesis pathways mediated by reduced secretion of reelin and also reduced expression of the PLA2G7 gene.

Keyphrases

ankylosing spondylitis
rheumatoid arthritis
disease activity
poor prognosis
oxidative stress
systemic lupus erythematosus
binding protein
gene expression
genome wide identification
bone regeneration