Hepatic Acyl CoA Oxidase1 Inhibition Modifies Brain Lipids and Electrical Properties of Dentate Gyrus.

Shahrbanoo Rafiei Fariba Khodagholi Hamid Gholami Pourbadie Leila Dargahi Fereshteh Motamedi

Published in: Basic and clinical neuroscience (2023)

The results indicated that systemic inhibition of ACOX1 causes hypo-excitability of neuronal cells. These results provide new evidence on the involvement of peroxisome function and hepatic ACOX1 activity in brain fatty acid profile and the electrophysiological properties of dentate gyrus cells.

Keyphrases

fatty acid
induced apoptosis
cell cycle arrest
resting state
white matter
cerebral ischemia
cell death
functional connectivity
signaling pathway
multiple sclerosis
blood brain barrier
cell proliferation
pi k akt
drug induced