Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity.

Eun-Young KimJi-Eun KimYoung-Eun KimBongkun ChoiDong Hyun SohnSi-On ParkYeon-Ho ChungYongsub KimWilliam H RobinsonYong-Gil KimEun-Ju Chang

Published in: Cell & bioscience (2023)

These results indicate that a deficiency in the function of parkin caused by a decrease in parkin expression in OCPs under the inflammatory condition may enhance inflammatory bone erosion by altering microtubule dynamics to maintain OC activity.

Keyphrases

oxidative stress
bone loss
bone mineral density
poor prognosis
soft tissue
bone regeneration
postmenopausal women
long non coding rna