Altered tricarboxylic acid cycle flux in primary myotubes from severely obese humans.
Kai ZouJ Matthew HinkleySanghee ParkDonghai ZhengTerry E JonesWalter J PoriesPamela J HornbyJames LenhardG Lynis DohmJoseph A HoumardPublished in: International journal of obesity (2005) (2018)
These data suggest that with severe obesity the partitioning of glucose toward anaerobic glycolysis in response to insulin is a resilient characteristic of human skeletal muscle. This altered glucose partitioning appeared to be due, at least in part, to a reduction in TCA cycle flux.
Keyphrases
- type diabetes
- skeletal muscle
- insulin resistance
- weight loss
- metabolic syndrome
- blood glucose
- endothelial cells
- adipose tissue
- glycemic control
- microbial community
- wastewater treatment
- electronic health record
- induced pluripotent stem cells
- bariatric surgery
- early onset
- high fat diet induced
- weight gain
- pluripotent stem cells
- big data
- sewage sludge
- deep learning
- blood pressure
- heavy metals