Characterization of mRNA Lipid Nanoparticles by Electron Density Mapping Reconstruction: X-ray Scattering with Density from Solution Scattering (DENSS) Algorithm.

Huy M DaoKhaled AboulFotouhAasim Faheem HussainAlexander E MarrasKeith P JohnstonZhengrong CuiRobert O Williams

Published in: Pharmaceutical research (2024)

Analyzing SAXS profiles based on DENSS algorithm to yield a reconstructed electron density based three-dimensional model can be a useful physicochemical characterization method in the toolbox to study mRNA-LNPs and facilitate their development.

Keyphrases

high resolution
machine learning
deep learning
electron microscopy
magnetic resonance imaging
fatty acid
computed tomography
high density
monte carlo
electron transfer
solid state