Simulation Modeling to Extend Clinical Trials of Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Early Breast Cancer.

Jinani JayasekeraJoseph A SparanoRobert J Gray Claudine Isaacs Allison W KurianSuzanne O'NeillClyde B SchechterJeanne S Mandelblatt

Published in: JNCI cancer spectrum (2019)

Our results confirmed a small benefit in chemotherapy among women aged 50 years and younger with RS 16-25. Simulation modeling is useful to extend clinical trials, indicate how uncertainty might affect results, and power decision tools to support broader practice discussions.

Keyphrases

clinical trial
early breast cancer
gene expression
phase ii
dna methylation
primary care
polycystic ovary syndrome
virtual reality
healthcare
open label
pregnancy outcomes
study protocol
radiation therapy
quality improvement
pregnant women
randomized controlled trial
advance care planning
single cell