Research Progress on Signaling Pathway-Associated Oxidative Stress in Endothelial Cells.
Ying LiangJiajia LiQin-Lu LinPing HuangLin ZhangWei WuYouchu MaPublished in: Oxidative medicine and cellular longevity (2017)
Studying the mechanisms of oxidative stress in endothelial cells is vital to the discovery of novel drugs for the treatment of cardiovascular disease. This article reviews the progress within the field of the role of oxidative responses in the physiology and growth of endothelial cells and emphasizes the effects of several main signal pathways involved in the oxidative stress of endothelial cells. Herein, we aim to provide scientific direction that can serve as a basis for researchers specializing in the signaling pathway of oxidative stress.
Keyphrases
- endothelial cells
- oxidative stress
- signaling pathway
- induced apoptosis
- cardiovascular disease
- dna damage
- high glucose
- diabetic rats
- ischemia reperfusion injury
- vascular endothelial growth factor
- pi k akt
- epithelial mesenchymal transition
- small molecule
- type diabetes
- randomized controlled trial
- heat shock
- cardiovascular risk factors
- metabolic syndrome
- combination therapy
- heat shock protein