Measuring urinary 8-hydroxy-2'-deoxyguanosine and malondialdehyde levels in women with overactive bladder.

Eda DokumacioğluOzay DemirayAli DokumaciogluArzu SahinTugba Mazlum SenSoner Cankaya

Published in: Investigative and clinical urology (2018)

Oxidative stress may be important in the pathophysiology of OAB, because levels of 8-OHdG and MDA are increased. Increased levels of 8-OHdG may be due to damaged nuclear and mitochondrial DNA as a result of oxidative attacks caused by free radicals. Nevertheless, further randomized and prospective studies with larger patient populations are needed.

Keyphrases

mitochondrial dna
oxidative stress
copy number
open label
randomized controlled trial
dna damage
clinical trial
phase iii
ischemia reperfusion injury
placebo controlled
cell death
signaling pathway
induced apoptosis
genetic diversity
heat shock