c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression.

R WangW ZhangZ DongY QiMichael HultströmX ZhouE Y Lai

Published in: Acta physiologica (Oxford, England) (2016)

Prostaglandin signalling through upregulated PTGER3 activates JNK which reduces GAD1 and GABRA1 expression in the PVN, and contributes to sympathoexcitation in CHF.

Keyphrases

poor prognosis
binding protein
cell death
signaling pathway
high glucose
long non coding rna
diabetic rats
oxidative stress
protein kinase
tyrosine kinase
stress induced