Effects of dihydroartemisinin, a metabolite of artemisinin, on colon cancer chemoprevention and adaptive immune regulation.

Chong-Zhi WangChunping WanYun LuoChun-Feng ZhangQi-Hui ZhangLina ChenZhi LiuDaniel H WangMallory LagerCang-Hai LiTing-Liang JiangLifei HouChun-Su Yuan

Published in: Molecular biology reports (2022)

As a metabolite of ART, DHA possessed stronger anti-CRC activities. The DHA significantly inhibited cell growth via cell cycle arrest, apoptosis induction and anti-inflammation actions. The adaptive immune regulation is a related mechanism of actions for the observed effects.

Keyphrases

cell cycle arrest
cell death
pi k akt
oxidative stress
fatty acid
signaling pathway
endoplasmic reticulum stress
hiv infected
cell proliferation
plasmodium falciparum
drug administration