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The efficacy of combining adjuvants with non-surgical periodontal therapy in individuals with type 2 diabetes: A Bayesian network meta-analysis.

Fabrício Batistin ZanattaRaquel Pippi AntoniazziLeandro Machado OliveiraAdam D LietzanPatricia A MiguezCristiano Susin
Published in: Journal of clinical periodontology (2024)
Adjuvant use of metronidazole or alpha lipoic acid was the best adjunct option to provide clinically meaningful HbA1c levels and probing depth reductions. However, no strong recommendation can be drawn due to the scarcity of studies for each adjuvant treatment and the low certainty of the resultant evidence.
Keyphrases
  • systematic review
  • early stage
  • case control
  • optical coherence tomography
  • molecular dynamics simulations
  • randomized controlled trial
  • mesenchymal stem cells
  • network analysis