Effect of Intensive Blood Pressure Control on Kidney Outcomes: Long-Term Electronic Health Record-Based Post-trial Follow-Up of SPRINT.
Paul E DrawzKristin Macfarlane LenoirNayanjot Kaur RaiAnjay RastogiChi D ChuFrederic F Rahbari-OskouiPaul K WheltonGeorge ThomasAndrew McWilliamsAnil K AgarwalMaritza Marie SuarezMirela A DobreJames PowellMichael V RoccoJames P LashSuzanne OparilDominic S RajJamie P DwyerMahboob RahmanSandeep SomanRaymond R TownsendPriscilla PemuEdward HorwitzJoachim H IxDelphine S TuotAreef IshaniNicholas M PajewskiPublished in: Clinical journal of the American Society of Nephrology : CJASN (2023)
Intensive BP lowering was associated with a steeper total slope of decline in eGFR and higher risk for kidney events during the intervention phase of the trial but not during the post-intervention observation phase.
Keyphrases
- electronic health record
- randomized controlled trial
- study protocol
- blood pressure
- phase iii
- phase ii
- clinical trial
- small cell lung cancer
- clinical decision support
- epidermal growth factor receptor
- tyrosine kinase
- open label
- heart rate
- type diabetes
- hypertensive patients
- metabolic syndrome
- high intensity
- adipose tissue
- insulin resistance
- skeletal muscle
- weight loss
- placebo controlled