Resveratrol reduces oxidative damage and inflammation in mice infected with Trichinella spiralis.
Dina I ElgendyA A OthmanM A Hasby SaadN A SolimanS E MwafyPublished in: Journal of helminthology (2020)
Trichinellosis is a serious food-borne zoonotic infection of cosmopolitan distribution. Currently, treatment for trichinellosis is far from ideal. Given the important role of oxidative stress and immune-mediated inflammation in the pathogenesis of trichinellosis, this study was designed to evaluate the possible protective effects of resveratrol (RSV) during the intestinal and muscular phases of Trichinella spiralis infection in mice. The oral administration of RSV at a dose of 20 mg/kg once daily for two weeks resulted in significant reductions in both adult and larval counts; significant improvements in the redox status of the small intestine and muscles; a significant reduction in interleukin 4, pentraxin 3 and vascular endothelial growth factor expression; and the mitigation of intestinal and muscular inflammation. In conclusion, this study identifies RSV as a promising agent for the treatment of experimental trichinellosis, and more studies in experimental animals and humans are worth consideration.
Keyphrases
- oxidative stress
- vascular endothelial growth factor
- respiratory syncytial virus
- respiratory tract
- dna damage
- poor prognosis
- type diabetes
- physical activity
- high fat diet induced
- climate change
- gene expression
- metabolic syndrome
- diabetic rats
- resistance training
- insulin resistance
- adipose tissue
- dna methylation
- preterm birth
- aedes aegypti
- wild type