CD147 augmented monocarboxylate transporter-1/4 expression through modulation of the Akt-FoxO3-NF-κB pathway promotes cholangiocarcinoma migration and invasion.

Paweena DanaSaowaluk SaisomboonRyusho KariyaSeiji OkadaSumalee ObchoeiKanlayanee SawanyawisuthChaisiri WongkhamChawalit PairojkulSopit WongkhamKulthida Vaeteewoottacharn

Published in: Cellular oncology (Dordrecht) (2019)

Our data indicate that CD147 promotes the malignant progression of CCA cells by activating the Akt-FoxO3-NF-κB-MCT-1/4 axis. As such, CD147 may serve as a possible target for advanced CCA treatment.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
cell cycle arrest
cell proliferation
nk cells
poor prognosis
transcription factor
lps induced
oxidative stress
machine learning
nuclear factor
electronic health record
big data