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Boron-mediated one-pot access to salicylaldehydes via ortho -C-H hydroxylation of benzaldehydes.

Ruiyang WangXu FengBoya FengYu Chen
Published in: RSC advances (2024)
A novel protocol has been devised for the ortho -C-H hydroxylation of benzaldehydes. Directed by a transient imine group, the borylation of benzaldehydes, sequentially followed by the hydroxylation, furnishes diverse salicylaldehydes in a one-pot manner. The resultant salicylaldehydes could be readily applied in the downstream synthesis to produce bioactive molecules.
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