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Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms.

Lap HoKenjiro OnoMayumi TsujiPaolo MazzolaRisham SinghGiulio M Pasinetti
Published in: Expert review of neurotherapeutics (2017)
Our studies support the hypothesis that intestinal microbiota may help protect against AD, in part, by supporting the generation of select SCFAs, which interfere with the formation of toxic soluble Aβ aggregates.
Keyphrases
  • fatty acid
  • cognitive decline
  • case control
  • mild cognitive impairment