Primary Sjögren's syndrome independently promotes premature subclinical atherosclerosis.

Nadine ZehrfeldMalin AbelmannSabrina BenzClara Luisa ZippelSonja BeiderEmelie KramerTabea SeeligerGeorgios SogkasVega GödeckeGerrit AhrenstorfFranz Paul ArmbrusterThomas SkripuletzTorsten WitteAnselm Arthur DerdaKristina SonnenscheinDiana Ernst

Published in: RMD open (2024)

Subclinical atherosclerosis occurs earlier and more severely in patients with pSS. The difference in cIMT between pSS and controls seems mainly driven by patients with OI, suggesting that this subgroup is particularly at risk. OxLDL ab might protect against atherosclerotic progression in patients with pSS. CVR stratification and preventive medications such as Hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors should be discussed and further longitudinal studies are needed.

Keyphrases

cardiovascular disease
fatty acid
type diabetes
case control
disease activity
systemic lupus erythematosus
rheumatoid arthritis
phase iii
double blind