Integrative analyses of bulk and single-cell transcriptomics reveals the infiltration and crosstalk of cancer-associated fibroblasts as a novel predictor for prognosis and microenvironment remodeling in intrahepatic cholangiocarcinoma.
Yan-Jie ZhongXi-Mei LuoFei LiuZhi-Qiang HeSi-Qi YangWen-Jie MaJun-Ke WangYu-Shi DaiRui-Qi ZouYa-Fei HuTian-Run LvFu-Yu LiHai-Jie HuPublished in: Journal of translational medicine (2024)
This study reveals the key role of fibroblasts - oncocytes interaction in the remodeling of the immunosuppressive microenvironment in intrahepatic cholangiocarcinoma. Subsequently, it may trigger cascade activation of downstream signaling pathways such as PI3K-AKT and Notch in tumor, thus initiating tumorigenesis. Targeted drugs aimed at disrupting fibroblasts-tumor cell interaction, along with associated enrichment pathways, show potential in mitigating the immunosuppressive microenvironment that facilitates tumor progression.
Keyphrases
- single cell
- pi k akt
- signaling pathway
- rna seq
- stem cells
- cell proliferation
- extracellular matrix
- cell cycle arrest
- high throughput
- poor prognosis
- epithelial mesenchymal transition
- induced apoptosis
- cell therapy
- cancer therapy
- cell death
- oxidative stress
- climate change
- risk assessment
- mesenchymal stem cells
- network analysis
- endoplasmic reticulum stress