Integrin alpha-5 silencing leads to myofibroblastic differentiation in IPF-derived human lung fibroblasts.

Gali Epstein ShochetElizabetha BrookBecky Bardenstein-WaldHanna GrobeEvgeny EdelsteinLilach Israeli-ShaniDavid Shitrit

Published in: Therapeutic advances in chronic disease (2020)

ITGA5 expression facilitates a more aggressive proliferative phenotype. Downregulation of this integrin results in myofibroblastic differentiation, which is accompanied by elevated ITGA8. Specific targeting could present a therapeutic benefit.

Keyphrases

poor prognosis
idiopathic pulmonary fibrosis
cell proliferation
cell adhesion
signaling pathway
cell migration
cancer therapy
extracellular matrix
binding protein
long non coding rna
drug delivery