Enhanced immunosuppressive capability of mesenchymal stem cell-derived small extracellular vesicles with high expression of CD73 in experimental autoimmune uveitis.

Yanan DuanXiteng ChenHui ShaoYongtao LiZhihui ZhangHuan LiChuan ZhaoHong XiaoJiawei WangXiao-Min Zhang

Published in: Stem cell research & therapy (2024)

Over-expression of CD73 on MSC-sEVs enhances their immunosuppressive effects in EAU, indicating that sEVs-CD73 has the potential as an efficient immunotherapeutic agent for autoimmune uveitis.

Keyphrases

poor prognosis
juvenile idiopathic arthritis
multiple sclerosis
mesenchymal stem cells
ankylosing spondylitis
nk cells
bone marrow
binding protein
rheumatoid arthritis
drug induced
umbilical cord