MmCMS: mouse models' consensus molecular subtypes of colorectal cancer.
Raheleh AmirkhahKathryn GilroySudhir B MallaTamsin R M LannaganRyan M ByrneNatalie C FisherShania M CorryNoha-Ehssan MohamedHojjat Naderi-MeshkinMegan L MillsAndrew D CampbellRachel A RidgwayBaharak AhmaderaghiRichard MurrayAntoni Berenguer LlergoRebeca Sanz-PamplonaAlberto VillanuevaEduard BatlleRamon SalazarMark LawlerOwen J SansomPhilip D DunnePublished in: British journal of cancer (2023)
When applying human-based transcriptional classifiers to mouse tumour data, a pathway-level classifier, rather than an individual gene-level system, is optimal. Our R package enables researchers to select suitable mouse models of human CRC subtype for their experimental testing.